Synthesis of α-CF<sub>3</sub>-substituted <i>E</i>-dehydroornithine derivatives <i>via</i> copper(<scp>i</scp>)-catalyzed hydroamination of allenes
Anna N. Philippova, Daria V. Vorobyeva, Florian Monnier, Sergey N. Osipov
Abstract
An efficient synthetic approach to novel α-CF3-substituted E-dehydroornithine derivatives and their phosphorus analogues has been developed via the Cu(i)-catalyzed hydroamination of trifluoromethyl-containing α-allenyl-α-aminocarboxylates and α-allenyl-α-aminophosphonates with primary and secondary amines.
Topics & Concepts
HydroaminationCatalysisCopperChemistryMedicinal chemistryCombinatorial chemistryOrganic chemistryCatalytic Alkyne ReactionsCyclopropane Reaction MechanismsCatalytic C–H Functionalization Methods