Diastereoselective dearomative cycloaddition of bicyclobutanes with pyridinium ylides: a modular approach to multisubstituted azabicyclo[3.1.1]heptanes
Kushal Dhake, Kyla Woelk, Liam D N Krueckl, Faith Alberts, James Mutter, M. Pohl, Gilian T. Thomas, Muskan Sharma, Jaelyn Bjornerud-Brown, Nahiane Pipaón Fernández, Nathan D. Schley, David C. Leitch
Abstract
-rich drug candidates. These include semi-reduction of the dihydropyridine, and diastereoselective photochemical skeletal rearrangement to give a tetrasubstituted cyclobutane.
Topics & Concepts
PyridiniumCycloadditionPyridineChemistryCatalysisCombinatorial chemistryModular designMedicinal chemistryOrganic chemistryComputer scienceOperating systemRadical Photochemical ReactionsCatalytic C–H Functionalization MethodsSynthesis and Catalytic Reactions