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Effect of the dichloro-substitution on antiproliferative activity of phthalimide-thiazole derivatives. Rational design, synthesis, elastase, caspase 3/7, and EGFR tyrosine kinase activity and molecular modeling study

Beata Donarska, Marta Świtalska, Wojciech Płaziński, Joanna Wietrzyk, Krzysztof Z. Łączkowski

2021Bioorganic Chemistry25 citationsDOI

Topics & Concepts

ChemistryTyrosine kinaseThiazoleElastasePhthalimideSubstitution (logic)KinaseBiochemistryStereochemistryPharmacologyCombinatorial chemistryEnzymeSignal transductionComputer scienceMedicineProgramming languageSynthesis and biological activityCytokine Signaling Pathways and InteractionsHER2/EGFR in Cancer Research
Effect of the dichloro-substitution on antiproliferative activity of phthalimide-thiazole derivatives. Rational design, synthesis, elastase, caspase 3/7, and EGFR tyrosine kinase activity and molecular modeling study | Litcius