Aromatic C–H bond functionalization through organocatalyzed asymmetric intermolecular aza-Friedel–Crafts reaction: a recent update
Anup Biswas
Abstract
The aza-Friedel-Crafts reaction allows an efficient coupling of electron-rich aromatic systems with imines for the facile incorporation of aminoalkyl groups into the aromatic ring. This reaction has a great scope of forming aza-stereocenters which can be tuned by different asymmetric catalysts. This review assembles recent advances in asymmetric aza-Friedel-Crafts reactions mediated by organocatalysts. The mechanistic interpretation with the origin of stereoselectivity is also explained.
Topics & Concepts
ChemistryFriedel–Crafts reactionStereocenterOrganocatalysisIntermolecular forceEnantioselective synthesisStereoselectivityRing (chemistry)CatalysisAromaticityCombinatorial chemistryOrganic chemistryStereochemistryMoleculeAsymmetric Synthesis and CatalysisCatalytic C–H Functionalization MethodsSynthesis of Indole Derivatives