A photo-triggerable aptamer nanoswitch for spatiotemporal controllable siRNA delivery
Deyao Zhao, Ge Yang, Qing Liu, Wenjing Liu, Yuhua Weng, Yi Zhao, Feng Qu, Lele Li, Yuanyu Huang
Abstract
A photo-triggerable aptamer nanoswitch was proposed for spatiotemporal regulation of siRNA delivery. Recognition between AS1411 and nucleolin was effectively blocked by a photo-labile complementary oligonucleotide, which could be reactivated with photo-irradiation, resulting in efficient tumor-targeted siRNA internalization and gene silencing in vitro and in vivo.
Topics & Concepts
AptamerInternalizationIn vivoGene deliveryChemistryNanotechnologyGenetic enhancementBiologyMolecular biologyMaterials scienceGeneCellGeneticsBiochemistryAdvanced biosensing and bioanalysis techniquesRNA Interference and Gene DeliveryPhotochromic and Fluorescence Chemistry