Direct Interstitial Decongestion in an Animal Model of Acute-on-Chronic Ischemic Heart Failure
William T. Abraham, Michael Jonas, Ranjeet M. Dongaonkar, Beth Geist, Yukie Ueyama, Kevin Render, Brad Youngblood, William W. Muir, Robert L. Hamlin, Carlos del Río
Abstract
Removal of excess fluid in acute decompensated heart failure (ADHF) targets the intravascular space, whereas most fluid resides in the interstitial space. The authors evaluated an approach to interstitial decongestion using a device to enhance lymph flow. The device was deployed in sheep with induced heart failure (HF) and acute volume overload to create a low-pressure zone at the thoracic duct outlet. Treatment decreased extravascular lung water (EVLW) volume (mL/kg) (-32% ± 9%, P = 0.029) compared to controls (+46% ± 9%, P = 0.003). Device-mediated thoracic duct decompression effectively reduced EVLW. Human studies may establish device-based interstitial decongestion as a new ADHF treatment.