Saponins from <i>Panax japonicus</i> attenuate cognitive impairment in ageing rats through regulating microglial polarisation and autophagy
Xuejiao Pi, Qingqing Zhao, Jinxin Wang, Xu-lan Zhang, Ding Yuan, Shanshan Hu, Yumin He, Changcheng Zhang, Zhi-Yong Zhou, Ting Wang
Abstract
CONTEXT: (SPJ) exhibit anti-inflammatory and antioxidative effects. OBJECTIVE: To explore the neuroprotective effect of SPJ on natural ageing of rat. MATERIALS AND METHODS: . RESULTS: study also showed that SPJ regulated the microglial polarisation and autophagy. DISCUSSION AND CONCLUSIONS: SPJ improved cognitive deficits of ageing rats through attenuating microglial inflammation and enhancing microglial autophagy, which could be used to treat neurodegenerative disorders.
Topics & Concepts
Morris water navigation taskMicrogliaAutophagyAgeingNeuroprotectionProinflammatory cytokineCognitive declineChemistryInflammationHippocampusPharmacologyApoptosisMedicineInternal medicineDementiaBiochemistryDiseaseNeuroinflammation and Neurodegeneration MechanismsGinger and Zingiberaceae researchAlzheimer's disease research and treatments