Selective construction of polycyclic cyclohepta[<i>b</i>]indoles and cyclopenta[<i>b</i>]indoles <i>via</i> cycloaddition reaction of 3-(indol-3-yl)maleimides and (indol-2-yl)methanols
Jing Sun, Yan Chen, Yan Chen, Qiu Sun, Ying Han, Chao‐Guo Yan, Chao‐Guo Yan
Abstract
The polycyclic cyclohepta[ b ]indoles were efficiently obtained via a formal [4+3] cycloaddition and an unprecedented rearrangement of the maleimide motif from the C3/C2-position of the indole ring.
Topics & Concepts
ChemistryCycloadditionIndole testMaleimideRing (chemistry)StereochemistryMedicinal chemistryOrganic chemistryCatalysisAlkaloids: synthesis and pharmacologyChemical synthesis and alkaloidsAsymmetric Synthesis and Catalysis