Improving the Solubility and Bioavailability of Pemafibrate via a New Polymorph Form II
Long Li, Xian‐Hong Yin, Kai‐Sheng Diao
Abstract
of Form II is about 2.6 times that of Form I, indicating that the solubility and bioavailability of pemafibrate can indeed be improved by forming the new polymorph Form II. It may become an ideal solid form of active pharmaceutically ingredient suitable for pharmaceutical preparations, and it can be further studied in the later period.
Topics & Concepts
SolubilityCrystallinityBioavailabilityDissolutionDifferential scanning calorimetryCrystallizationChemistryMelting pointEnthalpyPolymorphism (computer science)CrystallographyNuclear chemistryOrganic chemistryThermodynamicsBiochemistryGenotypeBiologyBioinformaticsGenePhysicsCrystallization and Solubility StudiesComputational Drug Discovery MethodsPharmacological Effects of Natural Compounds