<i>In Vitro</i> Susceptibility of Kinetoplastids to Celastroloids from Maytenus chiapensis
Marvin J. Núñez, Morena L. Martínez, Atteneri López‐Arencibia, Carlos J. Bethencourt-Estrella, Desirée San Nicolás-Hernández, Ignacio A. Jiménez, Jacob Lorenzo‐Morales, José E. Piñero, Isabel L. Bazzocchi
Abstract
triggered by the mitochondria. In addition, the structure-activity relationship is discussed. These findings strongly underline the potential of celastroloids as lead compounds to develop novel antikinetoplastid drugs.
Topics & Concepts
BenznidazoleAmastigoteTrypanosoma cruziMiltefosineBiologyLeishmaniaLeishmania mexicanaPharmacologyIn vitroAntiparasiticChagas diseasePotencyLeishmaniasisMicrobiologyBiochemistryVirologyImmunologyParasite hostingVisceral leishmaniasisMedicineWorld Wide WebComputer sciencePathologyNatural Compounds in Disease TreatmentResearch on Leishmaniasis StudiesBioactive Compounds and Antitumor Agents