Compound screening in cell-based models of tau inclusion formation: Comparison of primary neuron and HEK293 cell assays
Alex Crowe, Mark J. Henderson, Johnathon D. Anderson, Steven A. Titus, Alexey Zakharov, Anton Simeonov, Arjan Buist, Charlotte Delay, Diederik Moechars, John Q. Trojanowski, Virginia M.‐Y. Lee, Kurt R. Brunden
Abstract
model. These results suggest that neurons, the cells most affected by tau pathology in AD, are very suitable for screening for tau inclusion inhibitors.
Topics & Concepts
HEK 293 cellsTau pathologySenile plaquesNeuronTau proteinNeuroscienceAlzheimer's diseaseCellReceptorChemistryBiologyCell biologyDiseasePathologyBiochemistryMedicineAlzheimer's disease research and treatmentsCholinesterase and Neurodegenerative DiseasesDementia and Cognitive Impairment Research