Glucose-6-phosphate dehydrogenase increases Ca<sup>2+</sup>currents by interacting with Ca<sub>v</sub>1.2 and reducing intrinsic inactivation of the L-type calcium channel
Rakhee Gupte, Vidhi Dhagia, Petra Ročić, Rikuo Ochi, Sachin A. Gupte
Abstract
In this study we have identified a novel isozyme of glucose-6-phosphate dehydrogenase (G6PD), a metabolic enzyme, that interacts with and contributes to regulate smooth muscle cell L-type Ca 2+ ion channel function, which plays a crucial role in vascular function in physiology and pathophysiology. Furthermore, we demonstrate that expression and activity of this novel G6PD isoform are increased in arteries of individuals with metabolic syndrome and in inhibition of G6PD activity in rats of metabolic syndrome reduced blood pressure.
Topics & Concepts
DehydrogenaseIsozymeCalciumGene isoformChemistryEnzymeVascular smooth muscleGlucose-6-phosphate dehydrogenaseBiochemistryEndocrinologyFunction (biology)Cell functionInternal medicinePhosphateBiophysicsBiologyCell biologyCellSmooth muscleGeneMedicineOrganic chemistryNeonatal Health and BiochemistryIon Transport and Channel RegulationDiet, Metabolism, and Disease