Members of the KCTD family are major regulators of cAMP signaling
Brian S. Muntean, Subhi Marwari, Xiaona Li, Douglas C. Sloan, Brian D. Young, James A. Wohlschlegel, Kirill A. Martemyanov
Abstract
Significance Neuromodulation is pivotal for brain function. One of the key pathways engaged by neuromodulators is signaling via second messenger cAMP, which controls a myriad of fundamental reactions. This study identifies KCTD5, a ubiquitin ligase adapter, as a regulatory element in this pathway and determines that it works by an unusual dual mode controlling the activity of cAMP-generating enzyme in neurons through both zinc transport and G protein signaling.
Topics & Concepts
Cell biologyBiologyPhosphodiesterase function and regulationProtein Kinase Regulation and GTPase SignalingSignaling Pathways in Disease