Vascularized tumor-on-a-chip to investigate immunosuppression of CAR-T cells
Rajul S Bains, Tara G Raju, Layla C Semaan, A Block, Yukiko Yamaguchi, Saul J. Priceman, Steven C. George, Venktesh S. Shirure
Abstract
observations showing limited CAR-T cell extravasation and effector function in solid tumors. Furthermore, they point to a specific role of M2 macrophages in driving CAR-T cell migration into and within the TME and could prove useful in the development of novel therapies to improve solid tumor CAR-T cell therapies.
Topics & Concepts
Chimeric antigen receptorImmunosuppressionImmunotherapyProstate cancerCancer researchMedicineAntigenCancerImmune systemImmunologyInternal medicineCAR-T cell therapy researchMicrofluidic and Bio-sensing Technologies3D Printing in Biomedical Research