Structural insights into the role of the acid-alcohol pair of residues required for dioxygen activation in cytochrome P450 enzymes
Tom Coleman, Jeanette E. Stok, Matthew N. Podgorski, John B. Bruning, James J. De Voss, Stephen G. Bell
Topics & Concepts
ChemistryMonooxygenaseStereochemistrySalt bridgeCytochrome P450Hydrogen bondResidue (chemistry)HemeThreonineProtein structureHelix (gastropod)MutantEnzymeBiochemistryMoleculeOrganic chemistrySerineSnailGeneBiologyEcologyPharmacogenetics and Drug MetabolismMetal-Catalyzed Oxygenation MechanismsDrug Transport and Resistance Mechanisms