Experimental Studies and Modeling of the Degradation Process of Poly(Lactic-co-Glycolic Acid) Microspheres for Sustained Protein Release
Paolo A. Netti, Marco Biondi, Mariaenrica Frigione
Abstract
-glycolic acid) microspheres (PLGA MS)for controlled protein release by double emulsion-solvent evaporation were produced and characterized for their morphological and technological features. MS autocatalytic degradation was described by a mathematical model based on a Michaelis and Menten-like chemical balance. Here, for the first time MS degradation was correlated to the advancement of MS degradation front with respect to the degraded radius, derived from mass loss experiments. The model can satisfactorily describe the kinetics of advancement of the degradation front experimentally derived for all MS formulations, especially when produced at higher PLGA concentrations.
Topics & Concepts
Glycolic acidPLGADegradation (telecommunications)Chemical engineeringEmulsionKineticsMicrosphereAutocatalysisMaterials scienceLactic acidChemistryOrganic chemistryNanoparticleCatalysisComputer scienceBacteriaEngineeringTelecommunicationsQuantum mechanicsGeneticsPhysicsBiologyAdvanced Drug Delivery SystemsProtein purification and stabilityDrug Solubulity and Delivery Systems