RNA-based pharmacotherapy for tumors: From bench to clinic and back
Xiangping Liang, Dongpei Li, Shuilong Leng, Xiao Zhu
Abstract
RNA therapy is a treatment that regulates cell proteins and cures diseases by affecting the metabolism of mRNAs in cells, which has cut a figure in the studies on various incurable illnesses like hereditary diseases, tumors, etc. In this review, we introduced the discovery and development of RNA therapy and discussed its classification, mechanisms, advantages, and challenges. Moreover, we highlighted how RNA therapy works in killing tumor cells as well as what progresses it has made in related researches. And the development of RNA anti-tumor drugs and the clinical trial process were also included.
Topics & Concepts
RNAMedicinePharmacotherapyClinical trialBench to bedsideBioinformaticsCancer researchComputational biologyBiologyInternal medicineMedical physicsGeneticsGeneRNA Interference and Gene DeliveryRNA modifications and cancerMicroRNA in disease regulation