Citrus tangerine pith extract alleviates hypoxia-induced ileum damage in mice by modulating intestinal microbiota
Yijing Yu, Ran Li, Lingling Pu, Cunyao Pan, Changjiang Guo, Xinxing Wang
Abstract
, suggesting that CTPE may be used as a prebiotic to regulate ecology of intestinal microorganisms. In addition, Spearman rank correlation analysis revealed that changed gut microbiota were significantly correlated with alteration of intestinal barrier function indexes. Taken together, these results indicate that CTPE effectively alleviates hypoxia-induced intestinal injury in mice and enhances intestinal integrity and barrier function by altering intestinal microbiota composition.
Topics & Concepts
IleumHypoxia (environmental)PrebioticProbioticProinflammatory cytokineGut floraBarrier functionBiologyDysbiosisHypobaric chamberCecumMicrobiologyInflammationImmunologyAndrologyChemistryInternal medicineEndocrinologyBiochemistryMedicineBacteriaAnatomyEffects of high altitude on humansOxygenCell biologyGeneticsOrganic chemistryHigh Altitude and HypoxiaDietary Effects on HealthChronic Obstructive Pulmonary Disease (COPD) Research