Isolation and identification of two new compounds from the seeds of <i>Moringa oleifera</i> and their antiviral and anti-inflammatory activities
Yongai Xiong, Muhammad Shahid Riaz Rajoka, MengXun Zhang, Zhendan He
Abstract
Eleven compounds were isolated from methanol extract taken from Moringa oleifera seeds, including two previously unknown and nine known compounds. These compounds were authenticated as a carbamate, three phenylglycosides, four phenol glycosides, two nucleosides, and one flavonoid. Their chemical structures were elucidated using 1 D/2D nuclear magnetic resonance and high resolution-MS. Antivirus activity analyses revealed that Moringa A, glucomoringin, and Vitexin possessed strong inhibitory effects against the H1N1 virus, having IC50 values in the range of IC50 = 0.26 ± 0.03, 0.98 ± 0.17, and 3.42 ± 0.37 μg/mL, respectively. Furthermore, these three compounds could decrease the levels of TNF-α, IL-6, and IL-1β, which occur in hosts because of H1N1 infections.