Global analysis of HLA-A2 restricted MAGE-A3 tumor antigen epitopes and corresponding TCRs in non-small cell lung cancer
Bei Zhang, Zhiyao Ren, Jianfu Zhao, Yue Zhu, Boya Huang, Chanchan Xiao, Yan Zhang, Jieping Deng, Lipeng Mao, Lei Tang, Dan Lan, Lijuan Gao, Hongyi Zhang, Guobing Chen, Oscar Junhong Luo
Abstract
This work identified candidate TCRs potentially suitable for TCR-T design targeting HLA-A2 restricted MAGE-A3 tumor antigen.
Topics & Concepts
EpitopeT-cell receptorAntigenCD8T cellCytotoxic T cellHuman leukocyte antigenCancer researchBiologyImmunotherapyCancer immunotherapyTumor antigenImmunologyImmune systemMolecular biologyIn vitroBiochemistryImmunotherapy and Immune ResponsesCAR-T cell therapy researchCancer Immunotherapy and Biomarkers