Synthesis of Axially Chiral Biaryls through Cobalt(II)‐Catalyzed Atroposelective C−H Arylation
Yong‐Jie Wu, Zhen‐Kai Wang, Zhen‐Sheng Jia, Jiahao Chen, Fan‐Rui Huang, Bei‐Bei Zhan, Qi‐Jun Yao, Bing‐Feng Shi
Abstract
Highly efficient synthesis of axially chiral biaryl amines through cobalt-catalyzed atroposelective C-H arylation using easily accessible cobalt(II) salt and salicyloxazoline ligand has been reported. This methodology provides a straightforward and sustainable access to a broad range of enantioenriched biaryl-2-amines in good yields (up to 99 %) with excellent enantioselectivities (up to 99 % ee). The synthetic utility of the unprecedented method is highlighted by its scalability and diverse transformations.
Topics & Concepts
CobaltCatalysisCombinatorial chemistryChemistryLigand (biochemistry)Salt (chemistry)Reaction conditionsOrganic chemistryReceptorBiochemistryAxial and Atropisomeric Chirality SynthesisCatalytic C–H Functionalization MethodsAlkaloids: synthesis and pharmacology