Multi-stimuli-responsive starch/MnO <sub>2</sub> microparticles hydrogel for synergistic chemoradiotherapy of breast cancer
Mozhdeh Dolati, Faranak Aghaz, Abbas Haghparast, Mehdi Jaymand, Elham Arkan
Abstract
Microparticles hydrogel sensitive to reduction, pH and radiation composed of starch (St) and MnO2 NPs were synthesized, and loaded with Dox for in vitro treatment of MCF-7 cells. LE and EE values were obtained as 3.12 and 93.4%, respectively. In vitro drug release study revealed pH- and reduction-responsiveness drug release behavior of the DDS. The intracellular uptake of the St/MnO2 microparticles was verified through FITC dye conjugation. The St-MnO2/Dox microparticles exhibited higher anticancer activity than free Dox after 48 h as verified by MTT and DAPI staining assays. As results, combined chemoradiotherapy approach exhibited synergistic outcomes than chemotherapy alone.