Visible-light-induced dearomative oxamination of indole derivatives and dearomative amidation of phenol derivatives
Lingang Wu, Yanan Hao, Yuxiu Liu, Haibin Song, Qingmin Wang
Abstract
Herein, we report a protocol for visible-light-induced dearomative oxamination reactions of indole derivatives to afford functionalized spirocyclic products. These step-economical reactions, which involve C-N and C-O bond formation, feature mild conditions, a broad substrate scope, high yields, exclusive diastereoselectivity and step-economy. In addition, a similar protocol could be used to synthesize spirolactams by dearomative amidation of phenol derivatives.
Topics & Concepts
Indole testPhenolChemistryCombinatorial chemistryOrganic chemistryRadical Photochemical ReactionsOxidative Organic Chemistry ReactionsAlkaloids: synthesis and pharmacology