A DNA logic gate with dual-anchored proximity aptamers for the accurate identification of circulating tumor cells
Tianshu Chen, Xin Fu, Qianqian Zhang, Dongsheng Mao, Yuchen Song, Chang Feng, Xiaoli Zhu
Abstract
We have designed a DNA logic gate that can integrate the recognition of multiple biomarkers with signal amplification to perform the accurate and sensitive analysis of circulating tumor cells (CTCs). It also has the potential to analyze rare cells that exist in small amounts but are of great significance (such as stem cells) in the fields of clinical diagnosis and biomedicine.
Topics & Concepts
AptamerIdentification (biology)Dual (grammatical number)DNAComputational biologyNanotechnologyComputer scienceChemistryMaterials scienceBiophysicsCancer researchCombinatorial chemistryBiologyMolecular biologyBiochemistryArtLiteratureBotanyAdvanced biosensing and bioanalysis techniquesBiosensors and Analytical DetectionNanopore and Nanochannel Transport Studies