Comprehensive transcriptomic profiling reveals SOX7 as an early regulator of angiogenesis in hypoxic human endothelial cells
Jeffrey A. Klomp, James Hyun, Jennifer E. Klomp, Kostandin V. Pajcini, Jalees Rehman, Asrar B. Malik
Abstract
encoding HIF-2α), inhibited both distinct and overlapping transcriptional programs. Our results indicated a role for HIF-1α in down-regulating mitochondrial metabolism while concomitantly up-regulating glycolytic genes, whereas HIF-2α primarily up-regulated the angiogenesis transcriptional program. These results identify the concentration and time dependence of the endothelial transcriptomic response to hypoxia and an early key role for SOX7 in mediating angiogenesis.
Topics & Concepts
AngiogenesisTranscriptomeHIF1ABiologyCell biologyTranscription factorHypoxia (environmental)Hypoxia-inducible factorsRegulatorVascular endothelial growth factorUmbilical veinVascular endothelial growth factor AGene expressionGeneCancer researchGeneticsChemistryOxygenVEGF receptorsOrganic chemistryIn vitroCancer, Hypoxia, and MetabolismCancer-related molecular mechanisms researchAngiogenesis and VEGF in Cancer