Respiratory support in a population-based ALS cohort: demographic, timing and survival determinants
Adriano Chiò, Cristina Moglia, Antonio Canosa, Umberto Manera, Rosario Vasta, Maurizio Grassano, Francesca Palumbo, Maria Claudia Torrieri, Luca Solero, Alessio Mattei, Fulvia Ribolla, Nicola Launaro, Fabiola De Marchi, Letizia Mazzini, Gabriele Mora, Andrea Calvo
Abstract
Respiratory support in a population-based ALS cohort: demographic, timing and survival determinants PostScript Figure 1 (A) Survival after non-invasive mechanical ventilation (NIMV) according to FVC% performed before NIMV (n=308). FVC% <50% (blue) 85 cases, median survival time 0.66 year (IQR 0.33-1.66); FVC% 50-59 (green) 48 cases, median survival time 0.84 (IQR 0.43-1.84); FVC% 60-69 (black) 85 cases, median survival time 1.08 (IQR 0.74-2.75), FVC% 70-79 (red) 65 cases, median survival time 1.34 (IQR 0.75-2.82), FVC% 80 (violet) 25 cases, median survival time 2.51 (1.49-5.00) (p<0.0001). (B) Survival after invasive mechanical ventilation (IMV) in patients who did (blue) and did not (green) undergo NIMV before performing IMV (p<0.014). (C) Survival from amyotrophic lateral sclerosis (ALS) onset. NIMV+IMV (violet), median survival time 6.09 (IQR 3.89->10); IMV alone (red) median survival time 3.40 (IQR 1.95-5.41) (p<0.0001); NIMV (blue) median survival time 2.84 (IQR 1.75-5.25); non-respiratory support (green) median survival time 2.41 (IQR 1.33-5.18).