<i>In Vivo</i> Generation of Organs by Blastocyst Complementation: Advances and Challenges
Konstantina-Maria Founta, Costis Papanayotou
Abstract
The ultimate goal of regenerative medicine is to replace damaged cells, tissues or whole organs, in order to restore their proper function. Stem cell related technologies promise to generate transplants from the patients' own cells. Novel approaches such as blastocyst complementation combined with genome editing techniques open up new perspectives for organ replacement therapies. This review summarizes recent advances in the field and highlights the challenges that still remain to be addressed.
Topics & Concepts
Regenerative medicineBlastocystComplementationBiologyStem cellFunction (biology)Computational biologyMedicineBioinformaticsComputer scienceCell biologyPhenotypeGeneticsEmbryoGeneEmbryogenesisPluripotent Stem Cells ResearchCRISPR and Genetic EngineeringTissue Engineering and Regenerative Medicine