The Major Autolysin Atl Regulates the Virulence of Staphylococcus aureus by Controlling the Sorting of LukAB
Xuhui Zheng, Sheya Xiao, Amelia St. John, Victor J. Torres
Abstract
mutant can be reversed through the supplementation of exogenous mutanolysin. Altogether, our study revealed that the cell wall hydrolase activity of Atl and the cleavage of peptidoglycan play an important role in controlling the sorting of S. aureus toxins during secretion.
Topics & Concepts
AutolysinPeptidoglycanBiologySecretionMicrobiologyExtracellularStaphylococcus aureusCell envelopeVirulenceAutolysis (biology)Cell biologyCell wallMutantBacteriaEnzymeBiochemistryEscherichia coliGeneGeneticsAntimicrobial Resistance in StaphylococcusAntimicrobial Peptides and ActivitiesToxin Mechanisms and Immunotoxins