Tetrazine- and<i>trans</i>-cyclooctene-functionalised polypept(o)ides for fast bioorthogonal tetrazine ligation
Kerstin Johann, Dennis Svatunek, Christine Seidl, Silvia Rizzelli, Tobias Bauer, Lydia Braun, Kaloian Koynov, Hannes Mikula, Matthias Barz
Abstract
Tetrazine- and<italic>trans</italic>-cyclooctene-functionalised polypeptides and polypetoids were prepared by ring-opening polymerisation of<italic>N</italic>-carboxyanhydrides using the respective functional initiators and shown to react in fast bioorthogonal tetrazine ligations.
Topics & Concepts
TetrazineBioorthogonal chemistryCycloocteneChemistryLigationCombinatorial chemistryBiochemistryOrganic chemistryMedicineSurgeryCatalysisClick chemistryClick Chemistry and ApplicationsChemical Synthesis and AnalysisMonoclonal and Polyclonal Antibodies Research