PHGDH-mediated endothelial metabolism drives glioblastoma resistance to chimeric antigen receptor T cell immunotherapy
Duo Zhang, Albert M. Li, Guanghui Hu, Menggui Huang, Fan Yang, Lin Zhang, Kathryn E. Wellen, Xiaowei Xu, Crystal S. Conn, Wei Zou, Mark B. Kahn, Seth D. Rhoades, Aalim M. Weljie, Serge Y. Fuchs, Nduka Amankulor, Daniel Yoshor, Jiangbin Ye, Constantinos Koumenis, Yanqing Gong, Yi Fan
Topics & Concepts
Cancer researchImmunotherapyChimeric antigen receptorBiologyTumor microenvironmentReprogrammingImmune systemT cellCellCell biologyImmunologyTumor cellsBiochemistryCancer, Hypoxia, and MetabolismGlioma Diagnosis and TreatmentImmune cells in cancer