EVALUATION OF MICONAZOLE NITRATE PERMEABILITY THROUGH BIOLOGICAL MEMBRANE FROM DERMAL SYSTEMS
Magdalena Bîrsan
Abstract
The development of pharmaceutical products with miconazole nitrate (MN) can bring various benefits to patients of whom fungal infections are resistant to classic antifungal formulas. In medical practice, dermal systems, in the form of polymeric films, represent an alternative to other medical products. The proposed dermal films contain hydroxyethyl cellulose (HEC) as a hydrophilic and bioadhesive matrix polymer, with the addition of polyethylene glycol (PEG) as a low-absorption promoter, so that the antifungal have a slow penetration towards the dermis. This study aims to evaluate the in vitro permeability of MN through biological membrane (pig ear skin) at pH 7.4, during its release from two polymeric films. In vitro pig ear skin permeation studies indicated that the amount of the drug released after 24 h was 40% in the case of formulation FI and 32% in the case of formulation FII from the initial dose (40 mg). The concentration of 40% MN released can be considered an appropriate antifungal dose, with the benefit of being accumulated in the stratum corneum where it is maintained for up to 4 days.