Intra-Host Diversity of Dengue Virus in Mosquito Vectors
Amanda Makha Bifani, Tanamas Siriphanitchakorn, Milly M. Choy
Abstract
Dengue virus (DENV) is the most common arbovirus, causing a significant burden on both the economy and global healthcare systems. The virus is transmitted by Aedes species of mosquitoes as a swarm of closely related virus genomes, collectively referred to as a quasispecies. The level of genomic diversity within this quasispecies varies as DENV moves through various ecological niches within its transmission cycle. Here, the factors that influence the level of DENV quasispecies diversity during the course of infection in the mosquito vectors are reviewed.
Topics & Concepts
Viral quasispeciesArbovirusBiologyDengue feverDengue virusVirologyChikungunyaAedesVirusVector (molecular biology)Host (biology)Transmission (telecommunications)GenomeEvolutionary biologyGeneticsGeneHepatitis C virusElectrical engineeringEngineeringRecombinant DNAMosquito-borne diseases and controlZoonotic diseases and public healthInsect symbiosis and bacterial influences