Roles of RNA m6A modification in nonalcoholic fatty liver disease
Jian Tan, Yue-fan Wang, Zhihui Dai, Hao-zan Yin, Chenyang Mu, Si-jie Wang, Fu Yang
Abstract
NAFLD is a series of liver disorders, and it has become the most prevalent hepatic disease to date. However, there are no approved and effective pharmaceuticals for NAFLD owing to a poor understanding of its pathological mechanisms. While emerging studies have demonstrated that m6A modification is highly associated with NAFLD. In this review, we summarize the general profile of NAFLD and m6A modification, and the role of m6A regulators including erasers, writers, and readers in NAFLD. Finally, we also highlight the clinical significance of m6A in NAFLD.
Topics & Concepts
Nonalcoholic fatty liver diseaseFatty liverDiseaseMedicineBioinformaticsPathologicalInternal medicineBiologyRNA modifications and cancerCancer-related molecular mechanisms researchRNA Research and Splicing