A novel BCMA PBD-ADC with ATM/ATR/WEE1 inhibitors or bortezomib induce synergistic lethality in multiple myeloma
Lijie Xing, Liang Lin, Tengteng Yu, Yuyin Li, Shih‐Feng Cho, Jiye Liu, Kenneth Wen, Phillip A. Hsieh, Krista Kinneer, Nikhil C. Munshi, Kenneth C. Anderson, Yu‐Tzu Tai
Topics & Concepts
BortezomibCancer researchSynthetic lethalityDNA damageApoptosisBone marrowCHEK1Stromal cellMultiple myelomaBiologyDNA repairCell cycleChemistryCell cycle checkpointImmunologyDNABiochemistryGeneticsMultiple Myeloma Research and TreatmentsProtein Degradation and InhibitorsCancer therapeutics and mechanisms