Litcius/Paper detail

Tryptophan-derived microbial metabolites activate the aryl hydrocarbon receptor in tumor-associated macrophages to suppress anti-tumor immunity

Kebria Hezaveh, Rahul Shinde, Andreas Klötgen, Marie Jo Halaby, Sara Lamorte, M. Teresa Ciudad, Rene Quevedo, Luke Neufeld, Zhe Qi Liu, Robbie Jin, Barbara T. Grünwald, Elisabeth G. Foerster, Danica Chaharlangi, Mengdi Guo, Priya Makhijani, Xin Zhang, Trevor J. Pugh, Devanand M. Pinto, Ileana L. Co, Alison P. McGuigan, Gun Ho Jang, Rama Khokha, Pamela S. Ohashi, Grainne M. O’Kane, Steven Gallinger, William Wiley Navarre, Heather Maughan, Dana J. Philpott, David G. Brooks, Tracy L. McGaha

2022Immunity694 citationsDOIOpen Access PDF

Topics & Concepts

Aryl hydrocarbon receptorImmune systemBiologyImmunityMacrophageCancer researchKynurenineInnate immune systemReceptorImmunologyTryptophanBiochemistryIn vitroTranscription factorAmino acidGeneImmune cells in cancerTryptophan and brain disordersEpigenetics and DNA Methylation