Chemical-genetic interrogation of RNA polymerase mutants reveals structure-function relationships and physiological tradeoffs
Anthony L. Shiver, Hendrik Osadnik, Jason M. Peters, Rachel A. Mooney, Peter I-Fan Wu, Kemardo K. Henry, Hannes Braberg, Nevan J. Krogan, James C. Hu, Robert Landick, Kerwyn Casey Huang, Carol A. Gross
Topics & Concepts
BiologyRNA polymeraseMutantGeneticsGenetic screenComputational biologyPolymeraseTranscription (linguistics)PhenotypeSOS responseStringent responseFunction (biology)GeneEscherichia coliCell biologyPhilosophyLinguisticsRNA and protein synthesis mechanismsBacterial Genetics and BiotechnologyBacteriophages and microbial interactions