Regulation of integrin α5β1 conformational states and intrinsic affinities by metal ions and the ADMIDAS
Jordan M. Anderson, Jing Li, Timothy A. Springer
Abstract
to oxygen atoms. Mutation of the ADMIDAS increases the affinity of closed states and decreases the affinity of the open state and thus reduces the difference in affinity between the open and closed states. An important biological function of the ADMIDAS may be to stabilize integrins in highly discrete states, so that when integrins support cell adhesion and migration, their high and low affinity correspond to discrete on and off states, respectively.
Topics & Concepts
IntegrinAffinitiesBiophysicsCell adhesionAdhesionBiologySteady state (chemistry)Function (biology)Plasma protein bindingConformational changeCell adhesion moleculeBinding siteProtein structureStereochemistryBiochemistryMutationMetal ions in aqueous solutionMetalCell biologyChemistryOxygenKineticsDimerReceptorBinding pocketCell functionCell Adhesion Molecules ResearchTrace Elements in HealthIron Metabolism and Disorders