Neurodevelopmental defects and neurodegenerative phenotypes in human brain organoids carrying Parkinson’s disease-linked <i>DNAJC6</i> mutations
Noviana Wulansari, Wahyu Handoko Wibowo Darsono, Hye-Ji Woo, Mi‐Yoon Chang, Jinil Kim, Eun-Jin Bae, Woong Sun, Ju‐Hyun Lee, Il‐Joo Cho, Hyogeun Shin, Seung‐Jae Lee, Sang‐Hun Lee
Abstract
-PD recapitulates disease phenotypes and reveals mechanisms underlying disease pathology, providing a platform for assessing therapeutic interventions.
Topics & Concepts
OrganoidPhenotypeParkinson's diseaseDiseaseNeuroscienceBiologyClinical phenotypeHuman brainGeneticsMedicineGenePathologyNuclear Receptors and SignalingPluripotent Stem Cells ResearchCRISPR and Genetic Engineering