Development of rotational intraperitoneal pressurized aerosol chemotherapy to enhance drug delivery into the peritoneum
Soo Jin Park, Eun Ji Lee, Hee Su Lee, Jun‐Sik Kim, Sunwoo Park, Jiyeon Ham, Jaehee Mun, Haerin Paik, Hyunji Lim, Aeran Seol, Ga Won Yim, Seung‐Hyuk Shim, Beong-Cheol Kang, Suk‐Joon Chang, Whasun Lim, Gwonhwa Song, Jae‐Weon Kim, Nara Lee, Ji Won Park, Jung Chan Lee, Hee Seung Kim, On behalf of the KoRIA* trial group
Abstract
≤ .05) in all regions except for bowels. In RIPAC, the pharmacokinetic properties reflected hemodynamic changes during capnoperitoneum, and there were no related toxicities. Conclusively, RIPAC may have the potential to enhance drug delivery into the peritoneum compared to PIPAC.
Topics & Concepts
PharmacokineticsAerosolDrug deliveryDoxorubicinNozzleChemotherapyPenetration (warfare)MedicineMaterials scienceBiomedical engineeringPharmacologyChemistrySurgeryNanotechnologyMathematicsOrganic chemistryPhysicsOperations researchThermodynamicsIntraperitoneal and Appendiceal MalignanciesAppendicitis Diagnosis and ManagementHernia repair and management