Antidiabetic drug sitagliptin blocks cyclophosphamide cerebral neurotoxicity by activating Nrf2 and suppressing redox cycle imbalance, inflammatory iNOS/NO/NF-κB response and caspase-3/Bax activation in rats
Ademola C. Famurewa, Nnaemeka Tobechukwu Asogwa, Samson C. Ezea
Topics & Concepts
NeurotoxicityPharmacologyMalondialdehydeNitric oxide synthaseOxidative stressGlutathione peroxidaseSuperoxide dismutaseGlutathioneChemistryNitric oxideEndocrinologyInternal medicineToxicityMedicineBiochemistryEnzymeCancer-related cognitive impairment studiesChemotherapy-induced organ toxicity mitigationChemotherapy-induced cardiotoxicity and mitigation