Black Phosphorus: Degradation Mechanism, Passivation Method, and Application for In Situ Tissue Regeneration
Ling Peng, Nasir Mahmood Abbasi, Yao Xiao, Zhongjian Xie
Abstract
Abstract Nanomaterials have attracted ever‐increasing interest in tissue regeneration in the past few decades. As an emerging 2D layered nanomaterial, black phosphorus shows more promising potentials in organism restoration than other 2D materials, attributed to its extraordinary biodegradation ability, remarkable optical properties, and high payload of drugs and agents. The degradation products, i.e., phosphate, can be adsorbed by tissues for specific regeneration such as bone, yet the excessive degradation rate of black phosphorus will reduce its application performance and hazard the biological safety. First, a solid overview of the research topic about the balance between the degradation and stability of black phosphorus is provided. For this purpose, the recent research works on the degradation mechanism, and the passivation methods from both physical and chemical aspects are in detail summarized. In the next part, the biosafety of black phosphorus is compared with the biosafety of other 2D materials, and the latest research studies of black phosphorus used for tissue regeneration are provided. At last, the current challenges of black phosphorus are put forward; therefore, its future development direction and research focus applied in the field of tissue regeneration in vivo are derived.