Platelet membrane decorated exosomes enhance targeting efficacy and therapeutic index to alleviate arterial restenosis
Shan Lu, Ruihan Wang, Minghao Cai, Chen Yuan, Bin Gao, Daqiao Guo, Yisheng Xu, Weiguo Fu, Xiaohua Yu, Yi Si
Abstract
This biomimetic strategy may be leveraged to boost the therapeutic index of exosomes and realize the multifaceted treatment of arterial restenosis.
Topics & Concepts
MicrovesiclesRestenosisPlateletMedicineTherapeutic indexPlatelet activationMembranePharmacologyCardiologyInternal medicineChemistryDrugStentmicroRNABiochemistryGeneExtracellular vesicles in disease