Attenuation of Getah Virus by a Single Amino Acid Substitution at Residue 253 of the E2 Protein that Might Be Part of a New Heparan Sulfate Binding Site on Alphaviruses
Ningning Wang, Xiaofeng Zhai, Xiaoling Li, Yu Wang, Wanting He, Zhiwen Jiang, Michael Veit, Shuo Su
Abstract
by enhancing binding to HS. In summary, we have identified HS as a new attachment factor for GETV and the corresponding binding site in the E2 protein for the first time. Our research potentially improved understanding of the pathogenic mechanism of GETV and provided a potential target for the development of new attenuated vaccines and antiviral drugs.
Topics & Concepts
AlphavirusBiologyAlphavirus infectionVirologyAmino acid substitutionHeparan sulfateVirusBiochemistryGeneCellMutantVirology and Viral DiseasesViral Infections and VectorsMosquito-borne diseases and control