Synthesis of Substituted of Benzo[4,5]imidazo[1,2-<i>a</i>]pyrimidines through (3 + 2+1) Cyclization of 2-Aminobenzimidazole, Acetophenone, and <i>N</i>,<i>N</i>-Dimethylformamide as One-Carbon Synthon
Mengyi Guo, Xin Huang, Suzhen Li, Wanqian Ma, Aqin Liu, Xiuyu Zhang, Qiulin Kuang, Luoteng Cheng, Yibo Song, Xueyuan Hu, Jianyong Yuan
Abstract
An efficient method for the construction of benzo[4,5]imidazo[1,2- a ]pyrimidines using N, N -dimethylformamide as a one-carbon source and 2-aminobenzimidazoles and acetophenone as substrates through a one-pot, three-component cascade reaction is described. Spectra investigations indicated the fluorescent properties of selected products, exhibiting quantum yields 0.07–0.16 with maxima absorption at 266–294 nm and emission at 472–546 nm.
Topics & Concepts
AcetophenoneDimethylformamideChemistryFluorescenceAbsorption (acoustics)CascadePhotochemistryMedicinal chemistryOrganic chemistryCatalysisMaterials sciencePhysicsChromatographySolventQuantum mechanicsComposite materialSynthesis and Reactivity of HeterocyclesCatalytic C–H Functionalization MethodsPhenothiazines and Benzothiazines Synthesis and Activities