T Lymphocytes in Parkinson’s Disease
Elena Contaldi, Luca Magistrelli, Cristoforo Comi
Abstract
T cells are key mediators of both humoral and cellular adaptive immune responses, and their role in Parkinson's disease (PD) is being increasingly recognized. Several lines of evidence have highlighted how T cells are involved in both the central nervous system and the periphery, leading to a profound imbalance in the immune network in PD patients. This review discusses the involvement of T cells in both preclinical and clinical studies, their importance as feasible biomarkers of motor and non-motor progression of the disease, and recent therapeutic strategies addressing the modulation of T cell response.
Topics & Concepts
Immune systemParkinson's diseaseDiseaseNeuroscienceMedicineImmunologyCentral nervous systemBiologyPathologyNeuroinflammation and Neurodegeneration MechanismsParkinson's Disease Mechanisms and TreatmentsNuclear Receptors and Signaling