Crosslinked zwitterionic microcapsules to overcome gastrointestinal barriers for oral insulin delivery
Yuhong Ma, Qihang Li, Jingru Yang, Yuan Cheng, Caihua Li, Changshun Zhao, Wei Chen, Dechun Huang, Hongliang Qian
Abstract
the PAT1 pathway. Moreover, the oral administration of CB-MCs@INS exhibited an excellent hypoglycaemic effect and maintained normoglycemia for up to 8 h in diabetic mice, demonstrating the great potential of crosslinked zwitterionic microcapsules as an oral insulin delivery platform for diabetes therapy.
Topics & Concepts
InsulinChemistryBioavailabilityOral administrationPharmacologyDrug deliveryProdrugBiochemistryMedicineInternal medicineOrganic chemistryAdvanced Drug Delivery SystemsElectrospun Nanofibers in Biomedical ApplicationsPancreatic function and diabetes