Tunable Light‐Activated Platform for Controlled Hydrogen Sulfide Release with Tracking
Yuan Fang, Aoxin Guo, Lu Wang, Lulu Ning, Yuan Guo, Jianjian Zhang
Abstract
Abstract Hydrogen sulfide (H 2 S) is increasingly recognized for its critical role in various physiological and pathological processes. The development of synthetic donors with controllable release profiles is essential for elucidating H 2 S's complex involvement in cellular signaling, which remains a challenge. Herein, we report a diverse collection of photocaged N‐methylation thiocarbamates and thiocarbonates, designed to explore how electronic properties and the leaving efficiency of payloads affect H 2 S release behaviors. These compounds are engineered to release carbonyl sulfide (COS) following the removal of photoprotective group (PPG). The COS could be rapidly converted into H 2 S by carbonic anhydrase, and the entire reaction progression was monitored by changes in fluorescence signals. Furthermore, this H 2 S‐releasing platform is suitable for conjugation with active pharmaceutical ingredients, facilitating the creation of H 2 S‐releasing hybrid prodrugs. Collectively, this novel class of H 2 S donor not only provides valuable tool for H 2 S‐related research but also holds significant potential as therapeutic agent.