<i>N</i>-Acylethanolamine Acid Amidase (NAAA): Mechanism of Palmitoylethanolamide Hydrolysis Revealed by Mechanistic Simulations
Laura Scalvini, Andrea Ghidini, Alessio Lodola, Donatella Callegari, Silvia Rivara, Daniele Piomelli, Marco Mor
Abstract
The N-terminal cysteine hydrolase N-acylethanolamine acid amidase (NAAA) catalyzes the hydrolytic deactivation of the lipid messenger, palmitoylethanolamide (PEA), with optimal activity at acidic p...
Topics & Concepts
AmidaseChemistryPalmitoylethanolamideQM/MMAcylationNucleophileHydrolysisLeaving groupActive siteStereochemistryMolecular dynamicsCatalysisOrganic chemistryComputational chemistryBiochemistryReceptorCannabinoid receptorAgonistCannabis and Cannabinoid ResearchPancreatic function and diabetesDiet, Metabolism, and Disease