CXCL12-mediated HOXB5 overexpression facilitates Colorectal Cancer metastasis through transactivating CXCR4 and ITGB3
Weibo Feng, Wenjie Huang, Jie Chen, Chenyang Qiao, Danfei Liu, Xiaoyu Ji, Meng Xie, Tongyue Zhang, Yi‐Jun Wang, Mengyu Sun, Dean Tian, Daiming Fan, Yongzhan Nie, Kaichun Wu, Limin Xia
Abstract
Our study implicates HOXB5 as a prognostic biomarker in CRC, and defines a CXCL12-HOXB5-CXCR4 positive feedback loop that plays an important role in promoting CRC metastasis.
Topics & Concepts
Cancer researchMetastasisBiologyTranscription factorCXCR4Chemokine receptorGene knockdownColorectal cancerChromatin immunoprecipitationCancerPromoterGene expressionChemokineReceptorGeneticsGeneChemokine receptors and signalinginterferon and immune responsesCell Adhesion Molecules Research