Aloe polysaccharides ameliorate obesity-associated cognitive dysfunction in high-fat diet-fed mice by targeting the gut microbiota and intestinal barrier integrity
Ling Mo, Jingjing Li, Hangsun Lu, S. H. Lu, Henghui Fu, Bo Huang, Chaochao Zhao
Abstract
). Finally, we observed a significant correlation among cognition-related genes, gut microbiota, oxidative stress, and inflammation in the HF-AP group. Together, our findings suggest that altered gut microbiota composition and improved gut barrier integrity may be important targets for potentially improving high-fat diet-induced cognitive impairment.
Topics & Concepts
Gut floraOxidative stressPolysaccharideInflammationObesityGut–brain axisMedicineBiologyImmunologyEndocrinologyBiochemistryGut microbiota and healthPhytochemistry and biological activity of medicinal plantsDiet and metabolism studies